* A Dietary Supplement Longevity Support Pack provided by Douglas Laboratories®, supplies a comprehensive nutrient support system to assist the body during the natural changes of the aging process. FUNCTIONS Body cells and tissues are threatened continuously by damage caused by toxic free radicals and reactive oxygen species (e.g., peroxides) which are produced during normal oxygen metabolism, by other chemical reactions, and by toxic agents in the environment. Free radicals, once formed, are capable of disrupting metabolic activity and cell structure. When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues. The uncontrolled production of free radicals is thought to be a major contributing factor to accelerating the natural changes during the aging process. The products found in Longevity Support can help to support the body’s entire antioxidant defense and provide a complete nutritional system in a convenient pack. Ultra Preventive X now contains Metafolin, a patented, natural form of (6S) 5- methyltetrahydrofolate (5-MTHF) as well as 500 IU of vitamin D3 per serving. 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine. Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme (5,10- methylenetetrahydrofolate reductase (MTHFR)). In certain populations, the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences. Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Additional vitamin D3 (also known as cholecalciferol) has been added to this formula as numerous scientists now feel that supplementation with vitamin D at levels greater than previously thought necessary is critical to helping maintain overall health. Citrus Solu-Q: Citrus Solu-Q is a liquid filled capsule containing natural coenzyme Q10 in a patented, self-assembling nano-colloid system for enhanced absorption. When mixed with an aqueous system, this patented technology results in the formation of a nanocolloid containing solubilized CoQ10. This colloidal delivery system contains a highly uniform distribution of droplets that are typically less than 100 nm in diameter, and allows for enhanced absorption of coenzyme Q10. Tri-En-All 400: While many think that the term “vitamin E” refers to a single entity, it actually describes a family of eight different compounds known as the tocopherols and the tocotrienols. Both the tocopherols and tocotrienols are further divided into their alpha, beta, gamma and delta isomers. These two groups of compounds are similar with respect to their structure, but do have subtle molecular structure differences. The d-alpha tocopherol isomer is the most well-known form of vitamin E. However, recent scientific evidence indicates that gammatocopherol has excellent antioxidant abilities that complement the antioxidant ability of alphatocopherol. Like tocopherols, tocotrienols function as powerful antioxidants. In certain systems, there is evidence that tocotrienols may even possess greater antioxidant activity compared with tocopherols. N-Acetyl L-Cysteine: NAC is a precursor for the sulfur amino acid cysteine, and cysteine is used by the body to synthesize glutathione. Glutathione is a naturally occurring tripeptide which is a major component of two anti-free radical enzymes - glutathione peroxidase and glutathione reductase. As such, glutathione offers one mechanism for scavenging toxic free radicals and inhibiting peroxidation thereby slowing down free-radical catalyzed chain reactions. Glutathione per se is well absorbed in the intestine, and enters the blood and other extracellular compartments where it exerts much of its beneficial antioxidant effects. However, it can not effectively enter the cell. In contrast to glutathione, NAC is efficiently transported into the cell where it is readily converted to cysteine for glutathione synthesis. Thus, supplementation with NAC can raise intracellular glutathione levels. Alpha Lipoic Acid: Alpha-lipoic acid is unique among biological antioxidants, because it is soluble in both water and lipids. This allows it to neutralize free radicals just about everywhere in the body. Due to its unique sulfur-containing structure, alpha lipoic acid can scavenge several types of free radicals, such as the highly reactive hydroxyl, and singlet oxygen free radicals. It is also capable of suppressing the generation of free radicals in the first place, since alpha-lipoic acid chelates transition metals, such as iron and copper. Because alpha-lipoic acid is involved in so many different antioxidant functions in virtually all body tissues, it has been called the universal antioxidant. C-1000: Vitamin C (ascorbic acid) has numerous biological functions. Foremost, it is essential for the synthesis of collagen and glycosaminoglycans which are the building materials of all connective tissues, such as skin, blood vessels, tendons, joint cartilage and bone. Vitamin C is the required coenzyme for two groups of enzymes that catalyze the crosslinking of collagen fibers - lysyl hydroxylases and prolyl hydroxylases. As such, vitamin C is essential for normal wound healing and capillary health. FruiTEA-Max: FruiTEA-Max is a potent antioxidant combination of white tea, apple, pomegranate and blueberry extracts. Diets high in antioxidants, as well as supplementation with antioxidants have been shown to have a protective effect in reducing cellular damage caused by free radicals. Mediterranean Forte: The Mediterranean diet is typically defined as a diet consumed by those living in countries near the Mediterranean Sea (Greece, Italy, etc) and is rich in fruits, vegetables, olive oil and low in red meat and dairy products. This includes olive oil, avocado oil, fish oil, olive juice extract, muscadine grape powder, pomegranate extract, broccoli concentrate, and lycopene. Unlike the typical Western diet, the Mediterranean diet contains high amounts of monounsaturated fats (from olives) and is low in saturated fats. The Mediterranean diet and its cultural emphasis on physical activity may be why people consuming this type of traditional diet may enjoy greater cardiovascular benefits and remain healthy and active throughout the normal aging process.