Best hesperidin methyl chalcone, obtained from a quality source in Spain, is a methylated derivative of the bioflavonoid hesperidin. Hesperidin occurs in citrus fruits, particularly sweet oranges, tangerines and lemons, often in association with vitamin C. It was first discovered in 1827, but gained more attention in 1936 when the famed researcher Albert Szent-Gyorgyi reported that bioflavonoids contributed to lessening the circulatory problems associated with scurvy, a condition that results from vitamin C deficiency. After scientific investigations revealed that a crude extract of vitamin C was able to relieve symptoms that purified vitamin C could not, bioflavonoids in citrus were found to work synergistically with vitamin C. Among these citrus bioflavonoids, hesperidin is prominent in helping vitamin C to improve capillary strength, to such an extent that for many years it was termed “vitamin P.” In 1947, the methyl chalcone form was found to be more bioactive than native hesperidin and to work synergistically with vitamin C.