Bioequivalence studies conduct for the comparison of two medicinal products containing the same active substance. The studies provide an objective means of critically assessing the possibility of substituting one for the other. Bioequivalence focuses on the release of a drug substance from its same dosage from and subsequent absorption into systemic circulation. The aim of the present study is to carry out bioequivalence study on omeprazole sodium carbonate (20 mg) powder for suspension, under fasting conditions in 24 human healthy volunteers. The study was designed in such a manner that the formulation effect can be distinguished from other effects. A randomized, open label, balanced, two treatments, two periods, two sequence, single dose, cross over, bioequivalence study on omeprazole(20 mg)sodium bicarbonate powder for suspension under fasting condition in human 24 volunteers. The omeprazole sodium bicarbonate (20 mg) powder for suspension commonly used as antiulcer. Omeprazole sodium carbonate is a proton pump inhibitors which suppress gastric acid secretion.Omeprazole 20 mg powder for suspension is widely used in the treatment of gas.