Sistemnoe vospalenie — eto tipovoy patologicheskiy protsess, razvivayushchiysya pri sistemnom povrezhdenii i kharakterizuyushchiysya total"noy vospalitel"noy reaktivnost"yu endoteliotsitov, plazmennykh i kletochnykh faktorov krovi, soedinitel"noy tkani, i mikrotsirkulyatornymi rasstroystvami v zhiznenno vazhnykh organakh i tkanyakh. Priznaki sistemnogo vospaleniya vyyavlyayutsya ne tol"ko pri ostrykh septicheskikh sostoyaniyakh, no i pri khronicheskikh autoimmunnykh zabolevaniyakh. V dannoy rabote patogenez spondiloartritov rassmatrivaetsya s tochki zreniya ucheniya o sistemnom vospalenii, kak tipovom patologicheskom protsesse. Ustanovleno, chto pri spondiloartritakh vstrechayutsya tri varianta vospalitel"nogo otveta: klassicheskoe vospalenie s isklyuchitel"no mestnymi proyavleniyami, klassicheskoe vospalenie s sistemnoy vospalitel"noy reaktsiey i khronicheskoe sistemnoe vospalenie. Opredeleny chastoty vstrechaemosti chastnykh fenomenov sistemnogo vospaleniya pri izuchaemykh zabolevaniyakh. Vpervye proveden sravnitel"nyy analiz ekspressii tsitokinov i belkov ostroy fazy, a takzhe rasprostranennosti osnovnykh chastnykh fenomenov sistemnogo vospaleniya pri ankiloziruyushchem spondilite i khronicheskoy forme reaktivnogo artrita.