Khronicheskiy gepatit S (KhGS) kharakterizuetsya vysokoy chastotoy mul"tisistemnykh proyavleniy, sredi kotorykh vazhnoe mesto zanimaet patologiya pochek. Analiz literaturnykh dannykh i rezul"taty predstavlennogo issledovaniya svidetel"stvuyut o klinicheskoy i morfologicheskoy neodnorodnosti HCV-assotsiirovannogo porazheniya pochek, chto obuslovleno nalichiem razlichnykh mekhanizmov vozdeystviya virusa na renal"nye tkani. Tak, v khode raboty ustanovlena znachitel"naya rasprostranennost" khronicheskoy disfunktsii pochek u bol"nykh KhGS(34% (95% DI – 25-43%)), ee chetkaya assotsiatsiya s razvitiem vtorichnoy krioglobulinemii. Opisany sluchai uspeshnoy terapii krioglobulinemicheskogo glomerulonefrita u bol"nykh KhGS s ispol"zovaniem protivovirusnykh preparatov. Polucheny dannye o tom, chto sochetanie KhGS s glomerulopatiey privodit k bolee vyrazhennym klinicheskim i morfologicheskim proyavleniyam posledney i k snizheniyu effektivnosti renoprotektivnoy terapii. Pokazano, chto obnaruzhenie NS3-proteina HCV v razlichnykh tipakh kletok pochek yavlyaetsya kharakternoy chertoy glomerulopatiy u bol"nykh KhGS. V nefrobioptatakh ustanovleno nalichie retseptorov CD81, chto opredelyaet vozmozhnost" adgezii i posleduyushchego proniknoveniya virusa v kletki.