Provedennyy na osnove sovremennykh statisticheskikh metodov analiz izuchennykh kliniko-laboratornykh dannykh, variantov porazheniya razlichnykh organov i tkaney u bol"nykh s KhG-S, assotsiirovannym s krioglobulinemicheskim vaskulitom, pozvolil avtoru vydelit" kriterii differentsial"nogo diagnoza i prognoza etoy formy porazheniya pecheni. Podtverzhdena etiologicheskaya svyaz" nekotorykh form V-kletochnaya nekhodzhkinskoy limfomy s HCV-infektsiey, znachenie krioglobulinemii kak prediktora zlokachestvennoy V-kletochnoy limfoproliferatsii u bol"nykh KhG-S. Pokazana rol" kozhnoy sosudistoy purpury kak rannego priznaka krioglobulinemicheskogo vaskulita i prediktora porazheniya pochek. Razrabotan protokol vedeniya bol"nykh KhG-S s tyazhelym krioglobulinemicheskim vaskulitom. Opredeleny pokazaniya i effektivnost" monoklonal"nykh AT k CD 20 V-limfotsitov (rituksimaba) s posleduyushchey kombinirovannoy protivovirusnoy terapiey u bol"nykh s tyazhelymi proyavleniyami HCV-assotsiirovannogo krioglobulinemicheskogo vaskulita.