Vyyavlennoe nalichie autoimmunnykh proyavleniy u bol"nykh virusnymi gepatitami na rannikh etapakh zabolevaniya pozvolyaet rekomendovat" issledovanie syvorotki krovi bol"nykh OVG na nalichie markerov autoimmunnykh narusheniy (neorganospetsificheskie autoantitela, revmatoidnyy faktor, krioglobuliny) dlya resheniya voprosa o neobkhodimosti dal"neyshego nablyudeniya i prognozirovaniya techeniya zabolevaniya. Pri otsenke morfofunktsional"nogo sostoyaniya gepatobiobtatov u bol"nykh khronicheskimi virusnymi gepatitami V i S prognosticheskim kriteriem yavlyaetsya ne tol"ko gistologicheskaya aktivnost" i vyrazhennost" fibroza, no i subpopulyatsionnyy sostav leykotsitarnykh infil"tratov v parenkhime pecheni. V parenkhime pecheni etikh bol"nykh nami vpervye byl vyyavlen kompleks T-regulyatornykh kletok (CD4+CD25+), kotoryy vyzyvaet supressiyu kletochnogo immunnogo otveta pri eliminatsii virusa i povrezhdennykh tkaney i obespechivaet razvitie persistiruyushchey virusnoy infektsii s autoimmunnym komponentom.