Cocaine and Methamphetamine Dependence: Advances in Treatment provides a comprehensive summary of what psychiatrists and residents need to know about stimulant dependence and its treatment in order to move beyond the basics of this complex disorder. Ever-clearer evidence suggests stimulant dependence can be considered a brain disease. Indeed, neuroimaging studies indicate stimulant dependence may be acquired through epigenetic activation of a preexisting vulnerability in particular genes opening up opportunities to correct the underlying neurochemical abnormalities at the genetic level. Treatments for stimulant dependence are rapidly evolving, and this volume focuses on empirically validated treatments combining medication with behavior therapy. In addition, the authors report on a recent shift to more humane responses within the criminal justice system that has become crucial in obtaining treatment for the estimated 1.6 million cocaine and half-million methamphetamine users who abuse these drugs each day. Current, focused coverage of these and other key treatment considerations, such as HIV comorbidity and polydrug abuse, make this book essential reading for mental health clinicians.