The Adventures of C. H. Mouse is set, for the most part, in a rural area. C.H. is one of three children of Mr. and Mrs. Mouse. They get into trouble, as real children do, when they are young and curious. Grandfather Mouse comes to their rescue numerous times, sparing them from being hurt, from the big yellow cat to the owls in the woods. He imparts his wisdom on the Mouse children and tells them about the world outside their surroundings. Located at the end of the story are pages for the reader to create their own drawings to illustrate the book, making it personal for each individual child who reads it.