Modified layout with new and improved artwork. * Clinical Blue Boxes are now grouped to reduce interruption of text and are categorized with icons to promote easier comprehension of clinical information. * Expanded chapter introductory material includes Clinical Objectives and references to online case studies. * Companion website includes fully searchable online text, interactive cases, USMLE-style questions, and clinical Blue Box video podcasts. * Online faculty resources include an Image Bank and a Question Bank.