Temporomandibular disorders and chronic orofacial pain conditions are common sources of frustration to patients and clinicians. This book reviews current research on the mechanisms of temporomandibular and other orofacial pain conditions of muscle and joint origin, considers the biologic responses associated with temporomandibular disorders, and provides scientifically based recommendations on diagnosis and treatment. Useful to clinicians who treat patients with these conditions and researchers interested in the pathophysiology of muscle and joint pain.