Laser Florence 2010 is the annual Congress of the International Academy Laser Medicine and Surgery. The year 2010 is the fiftieth birthday of Laser and we celebrated it with a special edition. As usual researchers and doctors were shown new data immediately available for practical use, in different topics: Dentistry, Dermatology, Neurology, Rehabilitation and Sport Injuries, ENT, Phlebology, Plastic Surgery, Photodynamic Diagnosis and Therapy, Diabetology. A special session was dedicated to the role of laser beams and light in Energetic Medicine, now called Quantum Medicine and Regenerative Medicine. In fact, in the world there is a bit of confusion between data obtained from evidence based medicine and scientific data controlled experimentally. The aim of Laser Florence organisers is always the same: to establish an outstanding interaction between the delegates in a unique location and an unforgettable atmosphere where friendship, intelligence and scientific know-how are blended.