This text offers second-year medical students a case-based approach to learning mechanisms of renal disease. Each chapter covers a disease and begins with a patient case, followed by discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed in the text require students to apply their knowledge, and detailed answers to the questions are given. The Second Edition incorporates the latest findings regarding mechanisms of renal disease. This edition also has a two-color art program and a fresh new design that features cases, questions, and other pedagogical elements prominently.