At the heart of By Design are two inter-related movements. One is the science and religion dialogue, which stretches from the laboratories of Nobelists to inner sancta of the Vatican. This dialogue attempts to build bridges between two worlds formerly thought to be implacably hostile and incompatible. The other is the intelligent design movement, which by reviving a natural theology of design in nature has challenged the Darwinian strongholds in science and public education. Larry Witham introduces some of the most colorful characters in these movements, and summarizes the scientific developments that have made this dramatic new dialogue possible.