Pfizer Solitude IGR For feed-through fly prevention and control of house and stable flies in and around horses, horse barns, stables, paddocks and race tracks. When mixed 1/2 oz. into a horse"s ration daily according to the directions, will prevent house and stable fly development. Solitude IGR (cyromazine) is a non-organophosphate that has been safely used in horses since 2001 and undergone extensive research to prove its effectiveness and safety Repeated studies show up to 100% efficacy in inhibiting larvae development. Studies have proven it is 99.5% effective against stable flies and 100% effective against house flies with no effect on horses, other mammals or beneficial insects. Significant results may be observed within 2 weeks but the full benefit should be realized within 4-6 weeks of administration as the adult populations die off. Solitude IGR is intended for use only in equidae including horses, mules and donkeys. Cyromazine, the active ingredient in Solitude IGR, is an insect growth regulator that works on the fly"s chitin exoskeleton and is very species specific to house and stable flies. As the horse is fed cyromazine, it passes through the horse and is excreted in the manure. House flies and stable flies lay their eggs in the manure and the eggs subsequently hatch into the larval or maggot stage. (Cyromazine has no effect on the chitin of the adult fly.) As the maturing maggots feed on the manure treated with cyromazine, they become unable to successfully develop into adult flies because cyromazine inhibits the proper formation of chitin. The immature stage of the fly dies. Cyromazine has a well documented safety and efficacy profile. It has been extensively evaluated in horses since 2001 as well as intensely studied in other species for more than 20 years. Numerous environmental studies have documented cyromazine"s safety for mammals including humans and horses, as well as birds, daphnia, minnows and other indicator species. Once excreted, Solitude