This book constitutes the refereed proceedings of the 19th International Conference on Industrial and Engineering Applications of Artificial Intelligence and Expert Systems, IEA/AIE 2006, held in Annecy, France, in June 2006. The 134 revised full papers presented together with 3 invited contributions were carefully reviewed and selected from over 330 submissions. The papers are organized in topical sections on multi-agent systems, decision-support, genetic algorithms, heuristic search, data-mining and knowledge discovery, planning and scheduling, fuzzy logic, computer vision, case-based reasoning, knowledge engineering, machine learning, model-based reasoning, speech recognition, and systems for real life applications. There are 6 special sessions held in parallel with the general conference that focus on bioinformatics, ontology and text, data for discovery in engineering, intelligent control systems, intelligent systems for industry, and applications of data mining.