A group of internationally renowned experts in the field of cardiology and pharmacology discuss the latest state-of-art in nitrate therapy. Particular emphasis is put on isosorbide-5-mononitrate (IS-5-MN). The pharmacology, pharmacokinetics, and pharmacodynamics of such therapy are described as well as its methods of action, including such aspects as denitration, increase in cyclic guanosine-monophosphate, and the endothelium derived relaxant factor. The clinical part of the book deals with dosage, effectiveness, and the development of tolerance. The effect on ventricular hemodynamics and vasospastic angina is considered. Comparative studies of IS-5-MN with other nitrates, calcium antagonists, and beta blockers using exercise testing, Holter ECG recording, and invasive techniques provide a comprehensive survey of IS-5-MN treatment of coronary heart diseases. Also summarized is the state-of-the-art regarding silent myocardial ischemia, its treatment, and models of pain perception. Mononitrate II is the follow-up volume to the previous book on mononitrates in the series International Boehringer Mannheim Symposia.