S-Adenosylmethionine. Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function. The tablets should be given on an empty stomach at least one hour before feeding. The usual dose in cats and dogs is based on weight. For pets up to 12 pounds give 1 tablet of the 90 mg strength. For pets 12 to 25 pounds give 2 tablets of the 90mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. Eg. A dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.