This book makes an attempt to provide evidence of the innovation processes across metropolitan regions studies based on the use of a common more rigid methodology. The comparison is based on three metropolitan regions situated in the South Western, South Eastern and Northern periphery of the European Union: the metropolitan regions of Barcelona, Vienna and Stockholm. These regions are sufficiently different in terms of history, culture and economy. The book offers a compact review of current conceptual and theoretical developments and valuable insights deriving from a cross-national interregional comparative empirical study. It provides specific answers about variations of metropolitan innovation systems in their innovation capacity and performance within the European Union. Broad research coverage makes it invaluable reading for researchers, profefessionals and graduate students in the subject areas.