Joico Re:nu Age Defy Re:nual Serum Refill Joico Re:nual Serum nourishes the scalp environment enhancing natural melanin production and strengthening hair follicles for the optimal growth of healthy pigmented hair. With scientifically-proven Japanese ingredients: Panax Ginseng Extract: This activates cells in the hair follicles to promote healthy development of hair improving elasticity and strength. Zanthoxylum Fruit Extract (Japanese Sansho Pepper): Activates pigment-producing melanocytes and promotes their migration back into the follicle to reduce growth of new grey hair. Hops Extract: Increases the number of melanocytes in the hair follicle.