The major treatise of the specialty is now reinforced with an increased emphasis on infectious disease, extensively updated pathology and the latest in molecules biology as it affects diagnosis and management of pulmonary disease. Leaders in the field combine their expertise in the review of AIDS, gene therapy, ARDS, management of cystic fibrosis, opportunistic tuberculosis, occupational lung disorders and more. The necessary biological substrate of lung anatomy and physiology serves as a prelude to exhaustive coverage of etiology, pathophysiology, diagnosis and treatment of all disorders.