Due to recent developments in the healthcare environment, the science of evidence-based medicine has gained momentum and begun to influence practice and health policy. Based on the idea that the busy practitioner needs to learn the evidence-based medicine skills before applying the tools to everyday practice, this succint handbook acquaints the reader with this timely method of problem solving. After reading this text, physicians will be able to more critically read the medical literature, develop new skills of self-learning, better evaluate clinical guidelines, understand the techniques and limitations of cost and outcomes assessment, and apply the aforementioned skills to clinical practice.