Biosintez belka yavlyaetsya vazhneyshim matrichnymprotsessom, otvetstvennym za realizatsiyu geneticheskoyinformatsii. V poslednee vremya interes k protsessuterminatsii translyatsii znachitel"no vozros v svyazi sotkrytiem sposobnosti belka eRF3/Sup35 drozhzheyperekhodit" v prionnoe sostoyanie, privodya kvozniknoveniyu priona [PSI+]. Priony mlekopitayushchikhprivodyat k neizlechimym zabolevaniyam tsentral"noynervnoy sistemy, chto obuslavlivaet ogromnuyuprakticheskuyu tsennost" ikh izucheniya. Prion [PSI+]drozhzhey S. cerevisiae predstavlyaet soboy prostuyu iudobnuyu model" dlya izucheniya svoystv prionov kak unizshikh, tak i vysshikh eukariot. Sinteticheskayaletal"nost" (ili nesovmestimost") faktora [PSI+] imutatsiy v gene SUP45 obuslovlena odnovremennymnedostatkom belkov eRF1/Sup45 i eRF3/Sup35 v kletke.Na nesovmestimost" okazyvayut vliyanie faktory,izmenyayushchie kolichestvo etikh belkov, v tom chislesupressornye tRNK i belki-shaperony Hsp104, Ssb1,SSb2, Ssa1. Uvelichenie soderzhaniya S-terminal"nogodomena belka Sup35 v kletkakh S. cerevisiae privodit kuvelicheniyu kolichestva Sup45 i kompensatsiinesovmestimosti. Opisannyy fenomen mozhet byt"ispol"zovan dlya poiska novykh faktorov, vliyayushchikh naprionizatsiyu i/ili terminatsiyu translyatsii.