Perioperative medicine is the new face of anesthesiology with the role of the anesthesiologist expanding beyond the operating room more and more. With patient safety being the number-one priority of anesthesiologists, this issue explores the influence of perioperative care on outcomes, including topics such as monitoring, nutrition, and immune response. This must-read issue presents vital information to keep up with the changing role of today"s anesthesiologist. In this issue, you"ll find: How to assess risk and prevent complications inside the OR and outPharmacologic and nonpharmacologic strategiesAcute inflammation and its resolution, examining its biological checkpoints and linking it to stressInteractions of volatile anesthetics with endogenous and disease-associated proteins are described as well