This text explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects. Geared to undergraduate students who are less familiar with biological concepts but who have successfully completed typical first-year engineering mathematics, including differential and integral calculus and some differential equations. * A quantitative approach that includes physical and chemical principles * An integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiology. Illustration program reinforces the integrated nature of physiological systems * Pedagogically rich, including chapter objectives, chapter summaries, large number of illustrations, and short chapters suitable for single lectures * Clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.) * Problem sets provide opportunity for practice and assessment throughout the course.