Osmotics Lipofill Non-Surgical Filler Even more telling than lines and wrinkles, the loss of facial volume can dramatically age the face. As we age, skin can sag, become slack and lose the underlying support structure that defines healthy, youthful facial contours. This topical formula contains an effective combination of clinically proven ingredients to increase the natural renewal of subcutaneous fat to visibly plump and fill troubled areas while restoring skin resilience, firmness and tone. Perfect for nasolabial folds, puppet lines, cheeks, under eye hollows or any trouble zones experiencing loss of volume - even the back of the hands.