Avoca ASU is made by Nutramax Laboratories, Inc., the makers of Cosamin®DS, the #1 brand of glucosamine/chondroitin sulfate recommended by orthopedic surgeons and rheumatologists. Avoca ASU goes beyond the average glucosamine supplement. It is a potent combination of non-shellfish glucosamine and NMX1000TM avocado/soybean unsaponifiables (ASU), with OptiMSM® and decaffeinated green tea.NMX1000 avocado/soybean unsaponifiables is a potent compound that has been shown in cartilage cells to lower the production of several compounds involved in the process of cartilage breakdown in joints.OptiMSM is a pure form of MSM. MSM provides sulfur which is used by cartilage.