The Releve comprehensive joint formula is designed to support joint health in a more complete and scientific fashion, Releve contains glucosamine to help support joint health, but Releve"s main mechanism of action in supporting healthy joints is its patented COX-2 inhibiting ingredient IsoOxygene, What are the benefits of Releve: Releve employs a number of other benefits to help support joint health and bone health, Releve also contains substances that regulate the expression of enzymes in the cells that make bone, These are called osteoblasts, and they create or give rise to the musculoskeletal and connective tissue structures, As they mature, they are associated with the production of teeth and bone, Osteoclasts on the other hand, are responsible for the breakdown of bone, and effect the absorption and removal of bone, in other words, osteoclasts produce joint and bone degeneration, Under stress, various substances are produced in the body that result in swelling, soreness, and destruction of the cartilage in the joints, These substances are called mediators, but technically are known as cytokines and prostaglandin E-2 (PGE2), SKU: LNSTD180