Tylenol Arthritis Pain offers up to 8 hours of relief in an extended-release form. Tylenol Arthritis has a unique patented bilayer caplet. First layer dissolves quickly to provide prompt pain relief Second layer is time-released to provide up to 8 hours of relief Won"t damage your stomach the way aspirin can or irritate your stomach the way ibuprofen can. Since osteoarthritis (the most common form of arthritis) is primarily a problem of pain more than inflammation, many medical experts recommend that pain relief should be the primary goal of drug therapy.