NutralifePet SAMe Joint & Liver Supplement, 50mg tablets, 30 count; What is SAMe? SAMe or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. What is it for? SAMe is a great option for improving your pet"s liver health. How SAMe Works: SAMe contributes to better pet health through a number of chemincal processes: transmethylation, transsulfuration, and aminopropylation. These processes can affect liver, joint, and mood health in animals. If you"re using Denosyl, you should consider trying the NutralifePet SAMe products.