El Grapa escapa de la cárcel decidido a encontrar a su hermana María que se dice trabaja para Nicolás Quintero. Cuando un cargamento de mercancía del criminal sea robado, El Grapa encontrará la forma de adentrarse en su organización para dar con él. Los hombres de Nicolás y de mujer apodada La Culata lo perseguirán por entrometerse en sus asuntos. El Grapa cumplirá su misión a costa de su propia vida. Ahora será María la que siga adelante con la misión de destruir a toda la escoria que trafica con la droga. El Grapa manages to escape prison with the sole mission of finding María, his sister that it supposed to be working for a man named Nicolás Quintero. When a shipment of illegal goods is stolen from him, El Grapa finds a way to infiltrate the organization and locate him. Nicolás men and others commanded by a woman nicknamed La Culata are after him because he dared to step into their business. El Grapa finishes his mission at the cost of his own life. Now it will be up to María to keep fighting the scum that deals drugs.