There are now more than three hundred city-regions around the world with populations of more than one million. As globalization intensifies, these city-regions come to pose many new questions and problems. This book presents a highly original and multifaceted review of these issues by some of the leading researchers in the field. It seeks at once to define the question of global city-regions and to describe the internal and external dynamics that shape them; it proposes a theorization of global city-regions based on their economic and political responses to intensifying levels of globalization; and it offers a number of policy insights into the severe social problems that confront global city-regions as they come face to face with an economically and politically neoliberal world.