Since 1947 Extra Strength Shellfish-Free Promotes Health Joints Gluten, Wheat & Dairy Free Dietary Supplement Regenasure Glucosamine ...Made With... BioCell Collagen OptiMSMGlucosamine and Chondroitin both provide the essential building material glycosaminoglycans, which are required for healthy cartilage formation, promoting mobility, range of motion, flexibility and to ease occasional joint stress due to exercise or physical activity. MSM (Methylsulfonylmethane) provides a natural, bioavailable source of sulfur, an important mineral that also supports healthy collagen, connective tissue, joint cartilage and joint mobility. MSM works synergistically to increase the benefits of glucosamine and chondroitin. This formulation also provides Hyaluronic Acid.