By supplying a slow release form of D-glucaric acid, calcium D-glucarte is an effective agent that enhances the deactivation of toxic substances and encourages their elimination from the body. When calcium glucarate is converted to D-glucaro 1,4-lactone, it counteracts the enzyme beta-glucuronidase, which can otherwise interfere with conjugation and detoxification of steroid hormones and potentially carcinogenic compounds. Beta-glucuronidase enyzmes are present in all cells, particularly the liver, kidney, lung, intestinal epithelium, breast and endocrine organs. By inhibiting this enzyme, glucaric acid derivatives may exert a protective, non antioxidant effect on the immune system. Amni Calcium D-Glucarate, provided by DouglasLaboratories,. is a natural supplement of D-glucaric acidbound to calcium.Calcium D-glucarate enhances the bodys natural defensesagainst environmental toxins and excess steroid hormones.Through the actions of its metabolite D-glucaro-1,4-lactone,calcium-d-glucarate indirectly favors glucuronidation, animportant system that the body relies upon to deactivate andeliminate toxins and steroid hormones.Glucuronidation is a conjugation process through whichpotentially carcinogenic environmental toxins, such aspolycyclic aromatic hydrocarbons and nitrosamines, andexcess steroid hormones are neutralized. Duringglucuronidation, the enzyme glucuronosyl transferasecatalyzes the conjugation of free carcinogens and steroidhormones to glucuronic acid. The resulting glucuronideboundtoxins and hormones can then be safely excreted inbile and urine.The body also deconjugates glucuronide-bound endproducts. The release of glucuronide-bound substances isbeneficial in some circumstances, for example, when theexcretion of steroid hormones is undesirable. Yet, thedeconjugation process, which works via the enzyme betaglucuronidase,can result in the re-release of harmful toxinsback into the body.The benefits of calcium D-glucarate are realized indirectlythrough