Fibro Malic Cream is proven to work topical analgesic cream. When its active compound, capsaicin, is applied to the skin, it relieves pain rather than producing it. Unlike many pain relievers, capsaicin doesnt work by reducing inflammation. Instead, the compound blocks production and transport of substance P, which is a chemical that carries pain messages from nerve endings in your skin to control headquarters in your central nervous system. Muscle pain is caused by conditions such as osteoarthritis and fibromyalgia, whether or not there is inflammation. Studies show that fibromyalgia have low level of substance P.