CR Mimetic Longevity Formula 60 vegetarian capsules In 2003, the Life Extension Foundation® introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging process—many of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.”