This is a pure fruit enzyme formula made from the highest quality sources. ZymaCLENZ utilizes high dose bromelain, from pineapple, and papain, from papaya, exclusively from non-gmo sources. Immature tangerine and grapefruit enzymes complete the ZymaCLENZ makeup also adding much needed whole food vitamin C to the formula along with their enzymatic power. ZymaCLENZ should be taken on an empty stomach.