Increased range of motion in jointsresearch has shown that celadrin can have an impact on improving the range of motion in joints. a placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing celadrin for 2 months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.another study conducted on celadrin published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. the study found that the subjects given celadrin showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.maintains joint comfortthe anti-inflammatory actions of celadrin have been demonstrated by one double-blind, placebo controlled trial that showed celadrin, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. the authors theorize that celadrin may work by down-regulating the effect of certain precursors of the body’s inflammatory response.