Here"s today"s most authoritative and up-to-date information on basic and clinical electrophysiology. The 4th Edition covers everything from fundamental explanations of currents and channels, through the theoretical and experimental bases of cardiac electrical activity and arrhythmias, to current clinical understandings of arrhythmias and their treatment-and features the most comprehensive updating and revision to date.Covers today"s hottest topics, including HCN channels · stretch-activated channels · inward rectifier channels · contraction-excitation feedback · verve sprouting and arrhythmias · mechanisms of atrial fibrillation · mechanisms of ventricular fibrillation · transgenic and knockout models of cardiac arrhythmias · pharmacogenomics and cardiac arrhythmias · Brugada syndrome · and more.Features the expertise of 57 new contributors; and, existing contributors have revised and updated completely different chapters from previous editions.Presents 23 new chapters, including Stretch Activated Channels in the Heart · Biophysical Properties of Inward Rectifier Channels · Human Molecular Genetics and the Heart · Human Genetics of Channelopathies · and more.Includes revised and updated discussions of calcium channels · voltage regulated potassium channels · membrane pumps and exchangers · connexins · homomeric and heteromeric gap junctions · pharmacology of L-type and T-type channels in the heart · mechanisms of AV nodal excitability and propagation · theory of reentry · rotors and spiral waves in two dimensions · electrical remodeling and chronic atrial fibrillation · mechanisms of initiation of ventricular tachyarrhythmias · atrial fibrillation · ventricular tachycardia · long QT syndrome · Torsades de pointes · more!