This book deals with how changes in organ function can affect the way the body handles drugs. Most books on this subject deal with how drug treatments affect organ function. This book approaches it from the other way round. The information in this book will allow safer prescribing of drugs to critically ill patients. This is a clinical governance issue. Quality of care and quality of drug prescribing is vital to patient safety. With clinical governance and since the Audit Commission report on Intensive Care in the UK, this is even more spotlighted.