Volume forty-five of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. Articles in this volume cover such topics as Inhibins as Diagnostic Markers in Human Reproduction; uPA and PAI-1 in Breast Cancer: Review of Their Clinical Utility and Current Validation in the Prospective NNBC-3 Trial; Advances in Multiple Analyte Profiling; Immune Monitoring of Clinical Trials with Biotherapies; Dietary Modification of Brain Function: Effects on Neuroendocrine and Psychological Determinants of Mental Health and Stress Related Disorders; Menopause, Estrogen and Gonadotropins in Alzheimer Disease; Immunosuppression Routed via the Kynurenine Pathway: A Biochemical and Pathophysiologic Approach; Pathophysiology of Tumor-associated Macrophages.