This book constitutes the thoroughly refereed post-proceedings of the 6th International Workshop on Gesture in Human-Computer Interaction and Simulation, GW 2005, held in May 2005. The 22 revised long papers and 14 revised short papers presented together with 2 invited lectures were carefully selected from numerous submissions during two rounds of reviewing and improvement. The papers are organized in topical sections on human perception and production of gesture, sign language representation, sign language recognition, vision-based gesture recognition, gesture analysis, gesture synthesis, gesture and music, and gesture interaction in multimodal systems.