Buy Purederm Advanced Anti-Aging - Purederm Botanical Choice Wrinkle Reducer Gel Patches 6 Treatments. How-to-Use: Thoroughly clean and dry your face. Remove the patch from plastic liner. Apply the patch to appropriate area with shiny side facing your skin. Wear the patches for 30 minutes or overnight. Remove the patch, slowly from the edges. Rinse off any residue with water.