Science-Based NutritionTMDietary Supplement with 400mg Active S-Adenosyl Methionine per TabletEnhances Mood & Neural Function Promotes Joint Comfort & Mobility Supports Liver Health & Detoxification Pharmaceutical Grade60 Enteric Coated Tablets Sealed in Blister Packs for Freshness & ConvenienceOur Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet. Doctor"s Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.Double-Strength SAMe is sealed in blister packs for freshness and stability.S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.Supplementing with SAMeThe manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.