Ethnobotanical knowledge is a major component of indigenous knowledge systems which refers to a cumulative body of traditional knowledge about the interaction between human societies and the plant kingdom, and more specifically, how local people perceive, manage, and utilize the plant resources around them. This study examines the utilization of indigenous botanical plant resources in the former Kakamega District, Kenya. The study focuses on creating an inventory of indigenous botanical plant resources, their use, gender dynamics, impact of new technology, conservation measures and the quest for sustainable development.