Now a days longitudinal data analysis is very important in research areas and Longitudinal studies and binary outcome are common in health areas; this research could be used as a basis for future studies on health areas to show how to apply LMM, GEE, GLMM and MMM. This study can be the corner stone for future longitudinal studies about diabetes in Ethiopia and other countries. So this research will help for those researchers who want to conduct longitudinal data analysis.