This two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout both works are mathematical and computational approaches to examine central problems in the life sciences, ranging from the organizational principles of individual cells to the dynamics of large populations. Volume I covers a number of areas, including: Cellular Biophysics; Regulatory Networks; Developmental Biology; Biomedical Applications; Data Analysis and Model Validation.