Systane Lubricant Eye Drops works great during the day, but dry eye can also strike while you sleep. For overnight dry eye protection, there"s long - lasting SYSTANE NIGHTTIME Lubricant Eye Ointment. Designed to keep your eyes lubricated and comfortable throughout the night, SYSTANE NIGHTTIME creates a shield that locks in moisture to allow for healing. Available in 3.5 g preservative - free tubes of eye lubricant, SYSTANE NIGHTTIME helps provide overnight relief, when it is impractical to apply eye drops.