Pterostilbene Supreme, provides pterostilbene, a methylated resveratrol that is naturally occurring in berries. This formula also contains resveratrol, curcumin and vitamin D3 which can function synergistically with ptersostilbene to support healthy aging. Pterostilbene, a methylated form of resveratrol is considered the next generation of resveratrol. Pterostilbene has advantages over resveratrol: superior biological activity, better oral bioavailability, and slower metabolism in the body. pTeroPure pterostilbene is a nature identical form of trans-pterostilbene, a stilbene found in certain berries. The enhanced activity of pterostilbene compared to resveratrol may, in part, be explained by structural differences. Pterostilbene with two methoxy groups and one hydroxyl group has greater lipophilicity and a higher potential for cellular uptake than resveratrol, which has three hydroxyl groups. Pterostilbene showed strong inhibitory activity, much more than resveratrol, against a particular form of cytochrome P450. Researchers have suggested that these two compounds also work synergistically, supporting the theory that a combination of pterostilbene and resveratrol in a formulation may be more effective than using these ingredients separately. Both pterostilbene and resveratrol support mitochondrial function and healthy aging by activating SIRT1, one of the key enzymes of the sirtuin family. Sirtuins, a class of proteins, have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance, as well as energy efficiency and alertness during low-calorie situations. ? Pterostilbene also supports cardiovascular health; results from in vitro studies showed that pterostilbene acts as a PPARR agonist and may be a more effective PPARR agonist and hypolipidemic agent than resveratrol. In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects. ? Pterostilbene Supreme also contains Resvida, a pure resvera