DAP Appeasing Pheromone Diffuser Dog Refill 48ml 48ml Refill - For us with the D.A.P. Appeasing Pheromone Dog Collar In mammals, all lactating females release substances named"appeasing" pheromones, the purpose of which is to reassure the offspring. Research has shown that the reassuring properties persist, even into adulthood. The D.A.P. Diffuser contains an artificial version of this pheromone, which helps to control or prevent fear related reactions in puppies and adult dogs.The diffuser is suitable for use indoors and outdoors such as: Car journeys New environment (new home, strangers, kennels) Socialisation period Vet visits Unpredictable situations Other situations in which your dog may become distressed; traffic, other dogs, thunderstorms, gunshots etc. Helping puppies settle down in new environments away from the mother and siblings Helping rescue dogs settle into a new home with a new family The diffuser helps to reduce natural reactions of a distressed dog such as: Destruction Inappropriate toileting Vocalisation Salivation Vomiting Panting Excessive licking The D.A.P. Diffuser helps to establish a puppy in a new environment. 1 Diffuser lasts approximately 4 weeks Active from 50-70 Square Metres Plug in the D.A.P. Diffuser, in the room most used by the dog. Duration of use may differ, according to individual needs. REFILL ONLYSuitable for dogs only.